Pinealon (Glu-Asp-Arg) Vegan Pinealon Amino Acid – 10mg*

*Daily Value not established

Other ingredients:

Microcrystalline Cellulose, Gelatin and Calcium Stearate

Pinealon amino acid (plant derived)

Pinealon Brain Peptide Bioregulator

Pinealon is a synthetic tripeptide composed of glutamic acid, aspartic acid, and arginine. Studies in animal models indicate Pinealon could protect neurons from oxidative stress and hypoxia while potentially improving cognitive functions like memory and learning. Early findings point to Pinealon’s potential uses for age-related cognitive decline, sleep disorders, and neuroprotection.

Pinealon Research

Pinealon is a peptide complex composed of three amino acids: glutamine, asparagine, and arginine. It has been researched for its potential neuroprotective and cognitive-enhancing properties, particularly in relation to brain function and aging.

Neuroprotection: Pinealon may protect neurons from oxidative stress and hypoxia. Research suggests it could reduce reactive oxygen species and necrotic cell death in brain tissue. This potential neuroprotective effect may have implications for preventing or mitigating damage from strokes, traumatic brain injuries, and neurodegenerative diseases.

Gene Expression Regulation: Pinealon may interact directly with DNA to modify gene expression levels. Studies indicate it could penetrate cell and nuclear membranes, potentially regulating protein synthesis and cellular processes. This mechanism of action may contribute to its wide-ranging effects on brain function and cellular aging.

Cognitive Enhancement: Pinealon may improve memory, attention, and overall cognitive function. Research in both animal models and human trials suggests it could enhance learning ability and mental performance. These potential cognitive benefits may be particularly relevant for age-related cognitive decline and neurological disorders.

Circadian Rhythm Regulation: Pinealon may influence the pineal gland’s function, potentially affecting melatonin production and circadian rhythms. This could have implications for sleep regulation, mood disorders, and overall endocrine system balance. The peptide’s potential to modulate these processes may contribute to its broader effects on brain health and function.

Anti-Aging Effects: Pinealon may exhibit anti-aging properties at the cellular level, particularly in the central nervous system. Research indicates it could influence telomere preservation and potentially reverse some effects of cellular aging in the brain and spinal cord. These anti-aging effects may extend beyond the nervous system, potentially impacting other cell types throughout the body.

• Neuroprotection
• Brain Function
• Oxidative Stress
• Circadian Rhythm
• Memory Improvement
• Learning Enhancement
• Traumatic Brain Injury
• Alzheimer’s Disease

1. 1. 1. Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva IuE. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. Adv Gerontol. 2015;28(1):62-7. Russian. PMID: 26390612.
      2. Khavinson V, Linkova N, Kozhevnikova E, Trofimova S. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease. Molecules. 2020 Dec 31;26(1):159. doi: 10.3390/molecules26010159. PMID: 33396470; PMCID: PMC7795577.
      3. Mendzheritskiĭ AM, Karantysh GV, Ivonina KO. [Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats]. Adv Gerontol. 2011;24(1):74-9. Russian. PMID: 21809624.
      4. Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14(5):535-41. doi: 10.1089/rej.2011.1172. Epub 2011 Oct 6. PMID: 21978084.
      5. Kozina LS. [Investigation of antihypoxic properties of short peptides]. Adv Gerontol. 2008;21(1):61-7. Russian. PMID: 18546825.
      6. Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85. Epub 2012 Apr 6. PMID: 22567179; PMCID: PMC3342713.
      7. Karantysh, G. V. et al. “Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes.” Neurochemical Journal 14 (2020): 314 – 320.