Limitless Heart Vegan (Cardiogen)

Amount Per Capsule

Cardiogen (Ala-Glu-Asp-Arg) Vegan Cardiogen Amino Acid – 10mg*

*Daily Value not established

Other ingredients:

Microcrystalline Cellulose, Gelatin and Calcium Stearate

Cardiogen amino acid (plant derived)

Cardiogen Cardiovascular Peptide Bioregulator

Cardiogen is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Arg and a promising bioregulator in the field of cardiovascular research. This small peptide primarily targets fibroblasts, the cells responsible for tissue repair and scar formation. Findings from various studies suggest that Cardiogen may have the ability to stimulate cell proliferation in cardiac tissue, a process essential for maintaining a healthy heart. Moreover, it has been observed to reduce apoptosis, or programmed cell death, in myocardial cells by downregulating the expression of the p53 protein. Cardiogen also appears to boost the production of key cytoskeletal proteins, such as actin and vimentin, which play a key role in maintaining the structural integrity of cardiac cells.

Experiments conducted on rat models have yielded encouraging results, indicating that Cardiogen could potentially improve cardiac function by promoting the proliferation of cardiomyocytes, the primary cells responsible for heart muscle contraction. The bioregulator has demonstrated the capacity to reduce scar tissue formation, which is a common consequence of cardiac injury. Cardiogen has also shown promise in inducing apoptosis in tumor cells, suggesting its potential in oncology and cancer research.

Cardiogen Research

Tetrapeptide Cardiogen is a bioregulator with the amino acid sequence H-Ala-Glu-Asp-Arg-OH (AEDR). This peptide has been researched for its potential effects on cardiovascular function, tissue repair, and cellular regulation. Studies have explored its possible applications in heart health, cancer, and age-related conditions.

Cardiovascular Function: Cardiogen may stimulate cardiomyocyte proliferation while inhibiting fibroblast activity. This dual action could reduce scar formation and improve cardiac remodeling outcomes, potentially mitigating the progression of heart failure. Research suggests it might suppress p53 protein expression, which could decrease apoptosis rates in myocardial tissue.

Cellular Metabolism: Cardiogen may enter cells and travel through the cytoplasm, nucleus, and nucleolus. Studies indicate it could increase the expression of cytoskeletal proteins like actin, vimentin, and tubulin, as well as nuclear matrix proteins lamin A and C. This upregulation might activate intracellular metabolism and promote cell proliferation and differentiation.

DNA Interaction: Cardiogen may interact with specific DNA regions, potentially affecting gene expression. Research suggests it could prevent endonuclease-catalyzed DNA hydrolysis. This interaction with genetic material might explain its hypothesized role in regulating cellular functions and tissue regeneration.

Cancer Research: Cardiogen may exhibit contrasting effects on apoptosis in different cell types. While it might reduce apoptosis in cardiac cells, studies in rat models of M-1 sarcoma suggest it could increase apoptosis in tumor cells. Additionally, research has explored its potential to regulate signaling factors in prostate fibroblasts, which are implicated in prostate cancer development.

Product Focus

• Heart attack
• Hypertension
• Chronic heart failure
• Angina pectoris
• Coronary heart disease
• Myocardial hypertrophy
• Myocarditis
• Myocardiodystrophy
• Cancer (sarcoma)

Studies of Interest

1. 1. 1. Levdik NV, Knyazkin IV. Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats. Bull Exp Biol Med. 2009 Sep;148(3):433-6. English, Russian. doi: 10.1007/s10517-010-0730-9. PMID: 20396706.
      2. Chalisova NI, Lesniak VV, Balykina NA, Urt’eva SA, Urt’eva TA, Sukhonos IuA, Zhekalov AN. [The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats]. Adv Gerontol. 2009;22(3):409-13. Russian. PMID: 20210190.