Limitless Pancreas Vegan (Pancragen)

Amount Per Capsule

Pancragen (Lys-Glu-Asp-Trp) Vegan Pancragen Amino Acid – 10mg*

*Daily Value not established

Other ingredients:

Microcrystalline Cellulose, Gelatin and Calcium Stearate

Pancragen amino acid (plant derived)

Pancragen Pancreas Peptide Bioregulator

Pancragen is a naturally occurring tetrapeptide bioregulator composed of lysine, glutamic acid, aspartic acid, and tryptophan formulated to support pancreatic function. Research suggests Pancragen may upregulate expression of key factors involved in pancreatic cell maturation and differentiation, like Pdx1 and Pax6, potentially restoring functional activity. Animal studies indicate Pancragen can normalize insulin, C-peptide, and glucose levels, pointing to its ability to positively influence pancreatic endocrine function and metabolic balance. Pancragen shows promise for diabetes, pancreatitis, and age-related metabolic disorders.

Pancragen Research

Pancragen is a tetrapeptide bioregulator composed of Lys-Glu-Asp-Trp (KEDW) amino acid sequence. This ultrashort peptide has been the subject of research for its potential effects on pancreatic function, metabolic regulation, and age-related processes. Studies have explored its possible applications in diabetes management, endocrine function, and metabolic syndrome.

Pancreatic Function: Pancragen may help regulate the endocrine function of the pancreas. Research suggests it could potentially improve insulin secretion and glucose metabolism, which may have implications for managing blood sugar levels in individuals with diabetes or prediabetes.

Metabolic Regulation: This peptide bioregulator may play a role in modulating metabolic processes. Studies indicate that Pancragen could potentially reduce the incidence and severity of metabolic syndrome by influencing various metabolic pathways, including lipid metabolism and glucose homeostasis.

Melatonin Expression: Pancragen may affect melatonin expression in the body. This potential effect on the circadian rhythm regulator could have implications for sleep patterns, oxidative stress management, and overall cellular health.

Aging Processes: Research has explored Pancragen’s potential as an anti-aging compound for the pancreas. It may help mitigate some of the metabolic effects associated with aging by supporting pancreatic function and cellular regeneration.

Gene Expression: Pancragen, like other short peptides, may influence gene expression. Studies suggest it could potentially regulate the expression of genes related to pancreatic function and metabolism, which may contribute to its observed effects on endocrine and metabolic processes.

Product Focus

• Blood sugar control
• Chronic pancreatitis
• Pancreas endocrine function
• Melatonin regulation
• Metabolic syndrome reduction
• Type 2 diabetes mellitus
• Anti-aging effects

Studies of Interest

1. 1. 1. Khavinson VKh, Durnova AO, Polyakova VO, Tolibova GH, Linkova NS, Kvetnoy IM, Kvetnaia TV, Tarnovskaya SI. Effects of pancragen on the differentiation of pancreatic cells during their ageing. Bull Exp Biol Med. 2013 Feb;154(4):501-4. English, Russian. doi: 10.1007/s10517-013-1987-6. PMID: 23486591.
      2. Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA, Bondarenko EV. Prospects of using pancragen for correction of metabolic disorders in elderly people. Bull Exp Biol Med. 2011 Aug;151(4):454-6. doi: 10.1007/s10517-011-1354-4. PMID: 22448364.
      3. Goncharova ND, Ivanova LG, Oganyan TE, Vengerin AA, Khavinson VK. [Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys]. Adv Gerontol. 2015;28(3):579-585. Russian. PMID: 28509500.
      4. Heaton ES, Hu M, Liu T, Hui H, Tan Y, Ye K, Jin S. Extracellular matrix-derived peptide stimulates the generation of endocrine progenitors and islet organoids from iPSCs. J Tissue Eng. 2023 Jul 8;14:20417314231185858. doi: 10.1177/20417314231185858. PMID: 37435573; PMCID: PMC10331343.
      5. Goncharova ND, Ivanova LG, Oganian TÉ, Vengerin AA, Khavinson VKh. [Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys]. Adv Gerontol. 2014;27(4):662-7. Russian. PMID: 25946840.